November 22, 2015
Berkeley Lab researchers have developed nanoparticles that can carry therapeutics across the brain-blood barrier. They developed a new family of nanocarriers formed from the self-assembly of amphiphilic peptides and polymers. These new nanocarriers are called “3HM” for coiled-coil 3-helix micelles. Research results confirmed the effectiveness of 3HM as glioblastoma mutiforme (GBM) delivery vessels and also suggest that PET and MRI imaging of nanoparticle distribution and tumor kinetics may help improve the future design of nanoparticles for glioblastoma multiforme treatment.
Ting Xu, a nanoscience expert at Berkeley Lab, notes, “Our 3HM nanocarriers show very good attributes for the treatment of brain cancers in terms of long circulation, deep tumor penetration and low accumulation in off-target organs such as the liver and spleen.”