JNM Articles on Dose Optimization
- Letters to the Editor; J Duncan, M Lieber, N Adachi, R Wahl
Reply: Radiation Dose Does Matter: Mechanistic Insights into DNA Damage and Repair Support the Linear No-threshold Model of Low-Dose Radiation Health Risks (September 2018)
- Thernaostics - Basic; E Rousseau, J Lau, H Kuo, Z Zhang, H Merkens, N Hundal-Jabal, N Colpo, K Lin, F Benard
Monosodium Glutamate Reduces 68Ga-PSMA-11 Uptake in salivary Glands and Kidneys in a Preclinical Prostate Cancer Model (August 2018)
Evaluation of the ability of MSG to reduce salivary and kidney uptake of a PSMA radioligand without affecting tumor uptake.
- Oncology - Clinical; B Sah, S Ghafoor, I Burger E ter Voert, T Sekine, G Delso, M Huellner, K Dedes, A Boss, P Veit-Haibach
Feasibility of 18F-FDG Dose Reductions in Breast Cancer PET/MRI (June 2018)
Examines study results that determine the level of clinically acceptable 18F-FDG dose reduction in time-of-flight PET/MRI in patients with breast cancer.
- Molecular Targeting Probes Track - Dosimetry Models; J Brown, Y Li, E Frey, S Treves, F Fahey, D Plyku, G Sgouros, W Bolch
Assessing Patient Risk Undergoing Diagnostic Imaging With 99mTc-dimercaptosuccinic Acid as a Function of Waist Size, Renal Volume and Renal Depth (May 2018 abstract)
- Preclinical Radiation Dose Optimization, Dosimetry and Maximum Tolerated Dose Studies of Lu-177-labeled CTT1403 (May 2018 abstract) Building upon the superior therapeutic efficacy of CTT1403 in a PSMA+ PC3-PIP human xenograft model, responses were observed in mice receiving the treatment in transitional studies compared to controls.
- Issues and Controversies; J Siegel, B Greenspan, A Maurer, A Taylor, W Phillips, D Van Nostrand, B Sacks, E Silberstein
The BEIR VII Estimates of Low-Dose Radiation Health Risks Are Based on Faulty Assumptions and Data Analyses: A Call for Reassessment (February 2018)
Nuclear medicine physicians, radiologists and radiation professionals assess the interpretation of BEIR VII guidelines and call for the establishment of a BEIR VIII committee to reassess the validity, and use, of LNT and its derived policies.
- Continuing Education; F Fahey, A Goodkind, R MacDougall, L Oberg, S Ziniel, R Cappock, M Callahan, N Kwatra, S Treves, S Voss
Operational and Dosimetric Aspects of Pediatric PET/CT (July 2017)
This article describes the basics of CT dosimetry and PET/CT acquisition in children and the variability in pediatric PET/CT techniques, based on a survey of 19 PET/CT pediatric institutions in North America.
- Dose Optimization to Minimize Radiation Risk for Children Undergoing CT and Nuclear Medicine Imaging is Misguided and Detrimental; J Siegel, B Sacks, C Pennington, J Welsh (June 2017)
Radiology professionals evaluate evidence refuting the linear no-threshold model and corollary efforts to reduce radiation exposure from CT and nuclear medicine imaging in accord with the as-low-as-reasonable-achievable principle, particularly for children.
- SNMMI, ASNC, IAC and Nuclear Cardiology Dose (2017) Setting dose guidelines for nuclear cardiology procedures.
- Role of Reference Levels in Nuclear Medicine: A Report of the SNMMI Dose Optimization Task Force (September 2015)
Task forces members discuss some considerations for application of reference levels to nuclear medicine in response to the ICRP Committee 3 recommendations encouraging "authorized bodies to set diagnostic reference levels that best meet their specific needs and that are consistent for the regional, national, or local area to which they apply."
- Dose Optimization of the Administered Activity in Pediatric Bone Scintigraphy: Validation of the North American Consensus Guidelines; K Ayers, S Spottswood, D Delbeke, R Price, P Hodges, L Wang, W Martin (July 2015)
Vanderbilt University, Department of Radiology doctors compared the quality of lower-activity images with higher-activity images to determine whether the reduction in counts affects overall image quality in pediatric patients.
- Myocardial Perfusion Imaging with a Solid-State Camera: Simulation of a Very Low Dose Imaging Protocol (Jan 15 2013 ahead of print, limited access)
Ryo Nakazato and colleagues research the feasibility of very low dose myocardial perfusion imaging.
- Validation of an Automatic Dose Injection System for Ictal SPECT in Epilepsy (February 2012 abstract)
Setoain and colleagues investigate the performance and clinical usefulness of an automated injector system (AIS) that administers an automated injection for ictal SPECT after calculating the volume of tracer to be injected over time.
- Subjective Perception of Radiation Risk (December 2011 Supplement)
Freudenbergand Beyer review perceptions and concerns about radiation and radioactivity and conclude that it is extremely important to thoroughly and carefully educate all involved in patient work-up about radiation exposure levels and perceived or actual health risks.
- An Approach for Balancing Diagnostic Image Quality with Cancer Risk: Application to Pediatric Diagnostic Imaging of 99mTc-Dimercaptosuccinic Acid (December 2011)
Sgouros and colleagues describe a rigorous and critical approach to balancing the benefits of adequate image quality against radiation risks in children, using an example based in 99mTc-DMSA scanning.
- Virtual Reality for Dose Optimization in Pediatric Nuclear Medicine: Better Than the Real Thing (December 2011)
Zanzonico offers perspective on elements involved in balancing the benefits of advanced imaging techniques against risks of radiation exposure in young patients and previews a related article in this issue of JNM.
- Minimizing and Communicating Radiation Risk in Pediatric Nuclear Medicine (August 2011)
Fahey and colleagues provide an overview of radiation dosimetry for radiopharmaceuticals and CT, radiation risk estimation in pediatric nuclear medicine, approaches for communication of risk to patients’ families, and radiation dose reduction strategies.
- Cardiovascular Nuclear Imaging: Balancing Proven Clinical Value and Potential Radiation Risk - The Cardiovascular Council Board of Directors (July 2011)
Members of the SNM Cardiovascular Council Board of Directors summarize appropriate-use criteria and guidelines for minimizing radiation exposure and optimizing the clinical use of radionuclide cardiac imaging studies.
- Evaluation of Optimal Acquisition Duration or Injected Activity for Pediatric 18F-FDG PET/CT (July 2011)
Alessio and colleagues determine whether shorter acquisition durations or lower 18F-FDG injected activity could be used for pediatric 18F-FDG PET/CT examinations while maintaining diagnostic utility.
- 18F-FDG PET in Pregnancy and Fetal Radiation Dose Estimates (July 2011)
Takalkar and colleagues estimate the fetal radiation exposure resulting from 18F-FDG PET procedures performed in pregnant women with malignancies.
- Nuclear Medicine in the First Year of Life (June 2011)
Treves and colleagues provide an educational overview of imaging in children younger than 1 y, including clinical indications, methods, patient handling/positioning, sedation, radiopharmaceutical dosages, instrumentation, and radiation exposures and risk.
- Radioimmunotherapy in Non-Hodgkin Lymphoma: Opinions of Nuclear Medicine Physicians and Radiation Oncologists (May 2011)
Schaefer and colleagues report on the results of a survey of nuclear medicine and radiation oncology professionals on opinions and patterns of use of 90Y-ibritumomab tiuxetan and 131I-tositumomab radioimmunotherapy.
- Pediatric Radiopharmaceutical Administered Doses: 2010 North American Consensus Guidelines (February 2011)
Gelfand and colleagues describe the process by which the Pediatric Nuclear Medicine Dose Reduction Workgroup arrived at new consensus guidelines for pediatric administered doses for 9 commonly used radiopharmaceuticals.
- Changes in Radiation Dose with Variations in Human Anatomy: Moderately and Severely Obese Adults (June 2010)
Clark and colleagues describe dose assessment phantoms that model the influence of obesity on specific absorbed fractions and dose factors in adults.
- Changes in Radiation Dose with Variations in Human Anatomy: Larger and Smaller Normal-Stature Adults (May 2010)
Marine and colleagues assess variations in specific absorbed energy fractions in adults with different sizes but normal body stature.
- Improved Dose Regimen in Pediatric PET (February 2010)
Accorsi and colleagues determine quantitative injection rules for pediatric PET imaging that reduce scan time or dose while maintaining high image quality.
- Weight-Based, Low-Dose Pediatric Whole-Body PET/CT Protocols (October 2009)
Alessio and colleagues describe PET/CT acquisition protocols customized to children's weight and estimate the dosimetry and cancer risk associated with these low-dose procedures.
