PET/MR enterography offers potential in Crohn's disease

February 19, 2016

The combination of FDG-PET and MR enterography can accurately differentiate fibrotic strictures and inflammation in patients with Crohn's disease, potentially helping patients avoid unnecessary surgery, according to a new study published in the March issue of Radiology.

In a small preliminary study, researchers from Italy and Massachusetts General Hospital found that a combination of maximum standard update values (SUVmax), signal intensity on T2-weighted MR images, and apparent diffusion coefficient (ADC) values were the most effective biomarkers in distinguishing between patients with fibrosis and cases of fibrosis with active inflammation. The ultimate benefit for patients, the authors concluded, is that PET/MR enterography may have a "potential role" in distinguishing between patients who will need surgery and those who could be treated with noninvasive therapy.

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