Analysis finds variance in uptake of amyloid PET tracers

May 28, 2015

PET scans can detect varying levels of amyloid in the brain that change with age and the presence of a genotype linked to Alzheimer's disease, according to a Dutch study in the May Journal of the American Medical Association. The findings may enable clinicians to better tailor which patients receive the scans.

The study from researchers at VU University Medical Center in Amsterdam found that the average prevalence of abnormal amyloid PET scans among Alzheimer's patients decreased from 93% at age 50 to 79% at age 90. Meanwhile, the average prevalence among those with the apolipoprotein E (APOE) ε4 genotype remained above 90% regardless of age, but in those without the allele, it decreased from 86% at age 50 to 68% at age 90.

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