This Month in JNM

August 2, 2021

Editor's Page: 177Lu-PSMA617 and the VISION Trial: One of the Greatest Success Stories in the History of Nuclear Medicine. Page 1025

Discussions with Leaders: Johannes Czernin and Jérémie Calais talk with Michael Hofman, an Australian nuclear medicine physician and leader of international collaborative studies on prostate cancer, about innovation in clinical trial development. Page 1027

Hot Topics:
Targeted radionuclide therapy trials:
Mittra and Bodei review current trials in the National Institutes of Health database involving targeted radionuclide therapy, with an overview of the current landscape and future prospects. Page 1031

CE:
Pheochromocytoma and paraganglioma: Carrasquillo and colleagues provide an educational focus on these neuroendocrine tumors, emphasizing available imaging radiopharmaceuticals and the importance of genotype in selection of imaging agents. Page 1033

Focus on MI:
Molecular imaging of liver transporters:
Marie and colleagues describe characterization of hepatocyte transporters that have added to knowledge about 99mTc-mebrofenin kinetics and expanded the potential for translational and clinical applications assessing impaired liver function. Page 1043

Editorial:
18F-FDG for inflammation and infection: Wahl and colleagues laud the retirement of longstanding U.S. regulatory barriers to the use of 18F-FDG PET for inflammation and infection indications and call for additional local evidence gathering to support wider reimbursement. Page 1048

18F-FDG PET in metastatic prostate cancer: Wibmer and colleagues assess the prognostic value of 18F-FDG PET whole-body tumor burden parameters in patients with metastatic prostate cancer after first-line abiraterone or enzalutamide therapy. Page 1050

PET/CT- vs. CT-guided lung biopsy: Cerci and colleagues compare 18F-FDG PET/CT and CT performance in guiding percutaneous biopsies with histologic confirmation of suspect lung lesions. Page 1057

Combined PET/MRI and SLN N-staging: Weissinger and colleagues analyze the impact of 18F-FDG PET/MR imaging in addition to sentinel lymph node biopsy on accuracy of lymph node staging in patients with cervical cancer. Page 1062

Interim PET in DLBCL: Kurch and colleagues compare 3 competing methods of interim 18F-FDG PET evaluation using data from a large clinical trial including patients with diffuse large B-cell lymphoma. Page 1068

99mTc-PSMA I&S dosimetry: Urbán and colleagues estimate the dosimetry of 99mTc–prostate-specific membrane antigen I&S using a hybrid method and depict tracer biodistribution and tumor-to-background ratios in patients with prostate cancer. Page 1075

68Ga-PSMA-11 vs. 18F-rhPSMA-7: Kroenke and colleagues compare the frequency of non–tumor-related uptake and tumor positivity with 68Ga-PSMA-11 and 18F-rhPSMA-7 PET/CT in patients with primary or recurrent prostate cancer... Page 1082

Featured Clinical Article:
18F-Fluciclovine and radiotherapy decisions: Abiodun-Ojo and colleagues report on changes in salvage radiation treatment management based on 18F-fluciclovine PET/CT findings in patients with recurrent prostate cancer. Page 1089

131I-GMIB-Anti-HER2-VHH1 in HER2 therapy: D’Huyvetter and colleagues detail initial results on the safety, biodistribution, radiation dosimetry, and tumor-imaging potential of this targeted radionuclide theranostic agent in healthy volunteers and patients with breast cancer. Page 1097

19F/177Lu-rhPSMA-7.3 endoradiotherapy: Yusufi and colleagues describe preclinical evaluation, including biodistribution, dosimetry, and therapeutic efficacy, of this radiohybrid prostate-specific membrane antigen ligand and compare it with 177Lu-PSMA I&T. Page 1106

Low-dose 82Rb PET MPI: Lassen and colleagues evaluate the feasibility of performing myocardial perfusion imaging using either a half- or quarter-dose 82Rb protocol with reconstructions from acquired full-dose scans. Page 1112

Reducing 177Lu time points: Devasia and colleagues compare a novel method for joint time–activity estimation, based on a statistical mixed model, complete data from prior patients, and 1 or 2 imaging points, with single-time-point SPECT/CT dosimetry approaches. Page 1118

177Lu-DOTA-ZOL safety and dosimetry: Fernández and colleagues document the safety and dosimetry of a single therapeutic dose of this new therapeutic radiopharmaceutical for bone metastasis using a series of SPECT/CT images and blood samples. Page 1126

Special Contribution:
NRG–NCI Workshop on RPT Dosimetry:
Roncali and organizers/attendees review optimal and developing approaches applied clinically to calculate absorbed dose in radiopharmaceutical therapy as discussed at a 2018 joint NRG Oncology and National Cancer Institute workshop. Page 1133

Featured Article of the Month:
18F-Enzalutamide for androgen expression: Antunes and colleagues report on radiolabeling of this agent for PET assessment of androgen receptor density in prostate cancer and compare its in vitro and in vivo characteristics with those of 18F-FDHT. Page 1140

Fluorocarbon nanoemulsion for PET and MRI: Wang and colleague develop a functionalized nanoemulsion to serve as a platform for multimodal imaging probe exploration of molecular compositions enabling sensitive and precise imaging of inflammatory hotspots in vivo. Page 1146

Modeling 18F-Gln in breast cancer: Viswanath and colleagues detail model validation and performance assessment results for preclinical analysis and computer simulations of uptake kinetics of this PET agent that reflects glutamine transport and can be used to infer glutamine metabolism. Page 1154

Mapping arginase expression with PET: Clemente and colleagues report on the synthesis and evaluation of 2 radiolabeled arginase inhibitors, 18F-FMARS and 18F-FBMARS, with potential for PET staging of arginase-related pathophysiologies. Page 1163

SARS-CoV-2–related encephalitis: Tiraboschi and colleagues present notes on the contribution of 18F-FDG PET/CT imaging in a challenging case of neurologic manifestations in a patient with severe acute respiratory syndrome coronavirus 2 infection. Page 1171