May 2, 2017
Brain cancers are difficult to treat, and it can be hard to predict whether a therapy will be effective. When the patient is a child, it’s even more important to predict the potential effectiveness of a drug before beginning treatment. In this first ever molecular drug-imaging study in children, researchers in The Netherlands used whole-body positron emission tomography/computed tomography (PET/CT) scans to determine whether bevacizumab (Avastin) treatment of diffuse intrinsic pontine glioma (DIPG) in children is likely to be effective. The study is featured in the May 2017 issue of The Journal of Nuclear Medicine.
“Children with DIPG have a very poor prognosis, with less than 10 percent of the patients surviving two years from diagnosis,” explains Guus A. van Dongen, PhD, of VU University, Medical Center, Amsterdam, The Netherlands. “These tumors are resistant to all kinds of therapies. Chemotherapy, as well as new targeted therapies, may not reach the tumor due to the location within the brainstem.”