Diagnostic Efficacy of Gallium-68-PSMA-PET compared to Conventional Imaging in Lymph Node Staging of 130 consecutive Patients with Intermediate- to High-Risk Prostate Cancer

December 20, 2015

Current standard imaging techniques are insufficient to reliably detect lymph node (LN) metastases in prostate cancer (PCa). Recently, ligands of the prostate-specific membrane antigen (PSMA) have been introduced in PET imaging of PCa.

Thus, the aim of this retrospective analysis was to investigate the diagnostic efficacy of (68)Ga-PSMA-PET imaging for LN staging of patients with PCa scheduled for radical prostatectomy (RPX) and to compare it with morphological imaging (CT, MR) with histopathological evaluation as standard of reference.

From 12/2012 to 11/2014, 130 patients with intermediate to high-risk PCa were staged with (68)Ga-PSMA-PET/MR or PET/CT before RPX and template pelvic LN dissection. Histopathological findings of resected tissue were statistically correlated with the results of (68)Ga-PSMA-PET and morphological imaging in a patient- and template-based manner.

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