Molecular imaging of fungal infection using a Trojan horse

December 3, 2015

Scientists have been trying to develop radiotracers that will target and localize A. fumigatus infection. Although these radiotracers have demonstrated the potential to specifically target A.fumigatus, a lack of active uptake by the pathogen causes signal intensification at sites of infection. This has led Austrian researchers Hubertus Haas (Innsbruck Medical University) and colleagues to investigate an iron-uptake mechanism used by A.fumigatus, as a potential target for a radiotracer.

...In a proof of concept study, Haas and team showed that radiolabeling of desferri-siderophores, and in particular TAFC, was easily achievable with 68GA. ...Haas and team believe 68Ga-labeled siderophores and in particular 68Ga–TAFC, have the potential to be used as radiotracers for the specific targeting and localization of fungal infections. The 68Ga–TAFC complex rapidly reaches infection sites, where this “Trojan horse” is mistaken for a source of iron and taken up by the pathogen.

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