Two-Step Deposition of Amyloid Plaque in Parkinson's Disease

June 11, 2015

BALTIMORE — In patients with Parkinson's disease, the development of amyloid plaque might be a two-step process — cortical deposits followed by striatal deposits — new research suggests.

"The clinical implication is that the early detection of cortical-only plaques in patients may provide a window of therapeutic opportunities for anti-amyloid therapies," said investigator Nicolaas Bohnen, MD, from the University of Michigan School of Medicine at Ann Arbor.

In addition, the study results suggest that cholinergic denervation and amyloid plaques independently contribute to cognitive impairment in Parkinson's disease, Dr Bohnen told Medscape Medical News.

...Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2015 Annual Meeting: Abstract 29. Presented June 7, 2015.

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