PET/MRI could help diagnose kidney transplant infection

November 16, 2017

Researchers in Germany are developing a novel PET/MRI approach to determine whether a kidney transplant patient has developed an infection in the transplanted tissue, according to a study published in the November issue of the Journal of Nuclear Medicine.

The group used a highly specific CXCR4-targeted PET scan with gallium-68 (Ga-68) pentixafor. CXCR4 is a small receptor protein present on white blood cells fighting infection.

"This work establishes CXCR4-targeted PET as a novel approach for imaging of infection, and it strengthens the role of nuclear medicine for renal imaging," said Dr. Thorsten Derlin from Hannover Medical School. ...The PET/MRI scan could also help with other difficult-to-diagnose infections, such as cholangitis in transplant patients and bone infections, Derlin added.

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