This Month in JNM

October 2, 2017

Editor’s Page: Is 16 Months of Specialized Nuclear Medicine Training Enough for Best Patient Care? Czernin opens a dialogue on nuclear medicine training. Page 1535

Hot Topics: Nuclear Medicine Training: What Now? Mankoff and Pryma review the history of nuclear medicine training, discuss the needs for diversified modern practice, and suggest a path forward to address the evolving clinical specialty. Page 1536 

18F-FDG PET/CT in Lymphoma: Has Imaging-Directed Personalized Medicine Become a Reality? Barrington and Johnson summarize key clinical trial evidence that supports PET-directed personalized approaches in lymphoma, including a range of PET-guided therapeutic and management advances. Page 1539

PSMA Ligands for PET Imaging of Prostate Cancer: Schwarzenboeck and colleagues provide an educational overview of the current status of prostate-specific membrane antigen ligand PET imaging, including imaging procedures and interpretation, clinical indications, diagnostic potential, and impact on treatment planning. Page 1545

Pretargeted Imaging and Therapy: Altai and colleagues offer a brief survey of the 4 preeminent mechanistic approaches to pretargeting––strategies predicated on streptavidin and biotin, bispecific antibodies, complementary oligonucleotides, and bioorthogonal click chemistry. Page 1553

Factors Affecting Anti-PD-L1 Agents: Nedrow and colleagues evaluate the effect of protein concentration on distribution of 111In-DTPA–labeled anti-programmed cell death ligand 1 in a murine model of aggressive melanoma. Page 1560

18F-FMISO and Antiangiogenic Therapy: Grkovski and colleagues perform serial dynamic 18F-fluoromisonidazole PET imaging in rats to investigate changes in tumor biomarkers of perfusion and hypoxia after cediranib treatment. Page 1567

Hypoxia and Angiogenesis in Glioblastoma: Ponte and colleagues use 18F-fluoromisonidazole PET and conventional and perfusion MRI before surgery for in vivo and in situ characterization of hypoxia and angiogenesis in patients with glioblastoma multiforme. Page 1574

68Ga-DOTATATE PET/CT and Meningiomas: Kunz and colleagues analyze the diagnostic performance of 68Ga-DOTATATE PET/CT and contrast-enhanced MRI for detection of osseous infiltration in intracranial meningiomas using both qualitative and quantitative imaging parameters. Page 1580

Alternative 131I MPA Estimation: Nichols and colleagues report on a simplified method to obtain reliable maximum permissible activity values for 131I treatment in thyroid cancer, avoiding repeated g-camera whole-body measurements. Page 1588

18F-fluciclovine Reader Training: Miller and colleagues detail specific training and individual readers’ diagnostic performance, overall interpretation results, and interreader reproducibility for 18F-fluciclovine PET/CT images of patients with biochemically recurrent prostate cancer. Page 1596

18F-FLT PET in Myelofibrosis: Vercellino and colleagues compare tissue proliferation assessment with 18F-fluorothymidine PET to bone marrow histology/scintigraphy in evaluating severity of disease in patients with myelofibrosis. Page 1603

SSTR Antagonists in Breast Cancer: Dalm and colleagues investigate whether the application of a 111In-labeled somatostatin receptor antagonist can improve SSTR-mediated breast cancer imaging, with in vitro specimen panels and in vivo animal imaging and biodistribution studies. Page 1609

Agreement in PSMA PET/CT: Hofman provides perspective on the sometimes poorly defined concepts of reader agreement, reproducibility, and accuracy in diagnostic imaging, with a focus on prostate-specific membrane antigen PET/CT and a related article in this issue of JNM. Page 1615

68Ga-PSMA PET/CT Interobserver Agreement: Fendler and colleagues look at interobserver agreement in interpretation of 68Ga-PSMA-11 PET/CT for prostate cancer staging, including assessment of reader experience and recommendations for initial training. Page 1617

FEATURED ARTICLE OF THE MONTH – 225Ac-PSMA Therapy: Kratochwil and colleagues report on development of a treatment protocol for 225Ac-prostate-specific membrane antigen-617 therapy in advanced-stage, metastatic castration-resistant prostate cancer patients with PSMA-positive tumor phenotype. Page 1624

Quantitative Indices for PSMA PET/CT: Bieth and colleagues use 68Ga-PSMA PET/CT to assess 2 multimodal quantitative indices as imaging biomarkers for osseous tumor burden in recurrent prostate cancer. Page 1632

FEATURED TRANSLATIONAL SCIENCE ARTICLE – Doxorubicin and Myocardial Metabolism: Bauckneht and colleagues detail the results of a translational study designed to determine whether 18F-FDG PET/CT imaging can predict doxorubicin cardiotoxicity. Page 1638

TSPO PET, Fingolimod, and MS: Sucksdorff and colleagues explore the utility of serial 11C-(R)-PK11195 translocator protein–binding PET imaging in evaluating the effect of fingolimod treatment on microglial activation in patients with relapsing-remitting multiple sclerosis. Page 1646

PET and V1B Receptors: Koga and colleagues describe and assess a novel 11C-labeled pyridopyrimidin-4-one analog as a potent vasopressin 1B receptor radioligand, with potential for neuropsychiatric disease imaging and drug development studies. Page 1652

ESC Imaging After Genome Editing: Wolfs and colleagues induce stable expression of human imaging reporter genes in human embryonic stem cells and generate plasmids carrying reporter genes for fluorescence, bioluminescence imaging, and human PET reporter genes. Page 1659

18F-TFB Radiation Dosimetry: Doherty and colleagues report on the safety, biodistribution, and internal radiation dosimetry of 18F-tetrafluoroborate, a novel PET radioligand for imaging the human sodium/iodide symporter, in patients with thyroid cancer. Page 1666

Intrathecal Dosimetry Estimation: Hesterman and colleagues describe intrathecal-specific implementation of the 3-dimensional voxel-based internal dosimetry application to tailor dosimetry estimation for imaging investigations. Page 1672

FEATURED BASIC SCIENCE ARTICLE – Imaging Bacterial Infection: Gowrishankar and colleagues synthesize 6²-18F-fluoromaltotriose, a PET tracer with the potential to image and localize bacterial infections, and evaluate it in in vitro and in vivo studies. Page 1679

Macrophage Imaging in Pancreatitis: Foss and colleagues explore the hypothesis that 125I-iodo-DPA-713, a small-molecule radiotracer that specifically targets macrophages, can be used with SPECT/CT to image pancreatic inflammation in a mouse model. Page 1685

Scatter-Correction Techniques in PET/MR: Teuho and colleagues assess the impact of MR attenuation correction in scatter correction using 2 scatter-correction techniques and 3 MR-based attenuation image maps. Page 1691

Dose Reduction in PET/MRI: Seith and colleagues detail the effect of stepwise-reduced doses on objective and subjective image parameters and on oncologic readings in whole-body 18F-FDG PET/MRI. Page 1699