August 1, 2017
Yale University researchers have developed a way in which medical imaging could potentially be used to assess a patient's rupture risk for abdominal aortic aneurysm. Delaying surgical treatment can be life-threatening, and this new type of imaging could allow physicians to diagnose disease and better plan its management. The study is presented in the featured article of the August issue of The Journal of Nuclear Medicine.
Abdominal aortic aneurysm (AAA) accounts for 10,000 to 15,000 deaths each year in the United States. Matrix metalloproteinases (MMPs) play a key role in the development of AAA, which is especially prevalent in older men with a history of smoking. The researchers developed a novel, water-soluble MMP inhibitor that formed the basis for the new tracer, RYM1. In preclinical evaluation, RYM1 -- labeled with Tc-99m (99mTc) -- was then compared with another MMP tracer in mouse models of aneurysm.