Functional performance in patients with SLE linked to presence of DNRAbs

April 17, 2015

The presence of antibody to N-methyl-D-aspartate receptor in serum titers and resting brain hypermetabolism were linked to impaired memory function and mood alterations in patients with systemic lupus erythematosus, researchers found.

Serum titers of antibody to N-methyl-D-aspartate receptor (DNRAb) and [18F]2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) were explored in nine patients with short-term (disease duration of 2 years or less) systemic lupus erythematosus (SLE) and in eight patients with long-term (more than 10 years) SLE. Seventeen healthy control participants were also recruited.

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