PET-Adapted Salvage Therapy Achieves Negativity in Hodgkin Lymphoma

February 19, 2015

According to a new study published in the journal The Lancet Oncology, researchers have found that PET-adapted sequential salvage therapy with brentuximab followed by augmented ifosfamide, carboplatin, and etoposide (augICE) could optimize the chance of cure after high-dose therapy and autologous stem-cell transplant (HDT/ASCT) in patients with relapsed and refractory Hodgkin lymphoma.

For this open-label, single-center, phase 2 study, researchers enrolled 46 patients with relapsed or refractory Hodgkin lymphoma who had failed one previous doxorubicin-containing regimen. Patients received brentuximab vedotin 1.2mg/kg IV on days 1, 8, and 15 for two 28-day cycles, followed by a PET scan.

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