ATTR Amyloidosis

SNMMI currently offers several educational activities and resources designed to educate nuclear medicine physicians, cardiologists, technologists, and trainees on more accurately diagnosing and managing ATTR using non-invasive nuclear cardiology imaging techniques. 

New! Educational Vignettes

SNMMI has produced a series of educational vignettes* on more accurately diagnosing and managing Cardiac Amyloidosis. These short video vignettes will supplement the innovative educational programing currently being offered, educating the nuclear medicine community on the necessary background and practical skills for acquisition and interpretation of nuclear scans for diagnosis of ATTR-CM. 

Vignette #1: What is Amyloidosis?

Vignette #2: Cardiac Amyloidosis: Who is Affected

Vignette #3: Cardiac Amyloidosis: Evaluating Patients with Suspected Cardiac Amyloidosis

Upcoming Live Educational Activities

2022 SNMMI Mid-Winter and ACNM Annual Meeting
January 27-29, 2022 | Orlando, Florida

• Radionuclide Imaging in Cardiac Amyloidosis
  Presentations include:
  • Screening for Cardiac Amyloidosis
  • Appropriate Use Criteria in the Evaluation of Cardiac Amyloidosis
  • SPECT Imaging in Cardiac Amyloidosis
  • Cases in Cardiac Amyloidosis

On-Demand Educational Activities

• On-Demand Access Coming Soon: Cardiac ATTR Amyloidosis 2.0 – Looking into the Future
• Closing Knowledge Gaps in Transthyretin Cardiomyopathy
• SNMMI-TS Webinar: Cardiac Amyloidosis
• Multimodality Imaging of Cardiac Sarcoidosis and Amyloidosis
• FDG-PET/CT for Cardiac Device Infection Imaging
• Myocarditis/Pericarditis/Endocarditis Correlative Imaging
• Hot Topics in Nuclear Cardiology 2020: Case-Based Review

The Journal of Nuclear Medicine (JNM)

Added value of SPECT/CT compared to SPECT in^99mTc-PYP cardiac ATTR amyloidosis imaging
Kenneth Nichols, Se-Young Yoon and Christopher Palestro
Journal of Nuclear Medicine May 1, 2021, 62 (supplement 1) 1639;

ATTR Cardiac Amyloidosis: A direct comparison between conventional gamma camera heart/lung ratio quantification and D-SPECT methodology in 50 consecutive patients
Uzair Mahmood, Michael Feldkamp and Thomas Rosamond
Journal of Nuclear Medicine May 1, 2020, 61 (supplement 1) 1616;

Quantitative evaluation of 99mTc-pyrophosphate SPECT/CT in the diagnosis of transthyretin amyloid cardiomyopathy
Satoru Watanabe, Hiroto Yoneyama, Kenichi Nakajima, Hiroshi Wakabayashi, Anri Inaki, Junji Komatsu, Shohei Yoshida, Takahiro Konishi and Seigo Kinuya
Journal of Nuclear Medicine May 1, 2020, 61 (supplement 1) 1607;

3-D PYP Score for 3-hour uptake 99mTc Pyrophosphate SPECT-CT for Transthyretin Amyloid Cardiomyopathy
Ishan Garg, Andrew Hoffman, Martha Grogan, John Askew, Angela Dispenzieri, Steven Zeldenrust, Stephen Broski, Ann Packard and Geoffrey Johnson
Journal of Nuclear Medicine May 1, 2017, 58 (supplement 1) 35;

View The Journal of Nuclear Medicine (JNM) website for more results.

Consensus Documents

ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI Expert Consensus Recommendations for Multimodality Imaging in Cardiac Amyloidosis: Part 1 of 2-Evidence Base and Standardized Methods of Imaging
Sharmila Dorbala, Yukio Ando, Sabahat Bokhari, Angela Dispenzieri, Rodney H Falk, Victor A Ferrari, Marianna Fontana, Olivier Gheysens, Julian D Gillmore, Andor W J M Glaudemans, Mazen A Hanna, Bouke P C Hazenberg, Arnt V Kristen, Raymond Y Kwong, Mathew S Maurer, Giampaolo Merlini, Edward J Miller, James C Moon, Venkatesh L Murthy, C Cristina Quarta, Claudio Rapezzi, Frederick L Ruberg, Sanjiv J Shah, Riemer H J A Slart, Hein J Verberne, Jamieson M Bourque
J Card Fail. 2019 Nov;25(11):e1-e39. doi: 10.1016/j.cardfail.2019.08.001. Epub 2019 Aug 29.

ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: Part 2 of 2-Diagnostic criteria and appropriate utilization
Sharmila Dorbala, Yukio Ando, Sabahat Bokhari, Angela Dispenzieri, Rodney H Falk, Victor A Ferrari, Marianna Fontana, Olivier Gheysens, Julian D Gillmore, Andor W J M Glaudemans, Mazen A Hanna, Bouke P C Hazenberg, Arnt V Kristen, Raymond Y Kwong, Mathew S Maurer, Giampaolo Merlini, Edward J Miller, James C Moon, Venkatesh L Murthy, C Cristina Quarta, Claudio Rapezzi, Frederick L Ruberg, Sanjiv J Shah, Riemer H J A Slart, Hein J Verberne, Jamieson M Bourque
J Nucl Cardiol. 2020 Apr;27(2):659-673. doi: 10.1007/s12350-019-01761-5.

*The vignettes have been funded by a grant from Pfizer.